Core Body Temperature for Early detection of neurodegenerative diseases
This short note describes how wearable technologies can be employed to perform early detection of neurodegenerative diseases. A specific highlight is given to the use of Core Body Temperature monitoring for early detection of neurodegerative diseases.
A Virtual Wearable Sensor for Detection of Neurodegenerative Diseases
greenTEG won a grant to develop a new sensing solution for early detection of neurodegenerative diseases.
Authors: Giovanni Schiboni, Martin Rerabek, and Krzysztof Kryszczuk, ZHAW (Wädenswil); Philipp Eib, Fabien Rochat, Michele Zahner and Lukas Durrer, greenTEG AG (Zürich);Anneke Hertig-Godeschalk, David Schreier, Markus H. Schmidt, and Johannes Mathis, Inselspital (Bern)
greenTEG was awarded in July 2019 with an Innosuisse grant, together with the sleep and awake center of the University Hospital in Bern and the Zurich University of Applied Science (ZHAW).
This grant aimed to develop a sensor for wearable devices with the functionality of detecting early symptoms associated with Alzheimer’s and Parkinson’s diseases.
Since 2019, the thermal energy transfer sensor technology used in the CORE Body Temperature monitor has been successfully employed in a Swiss based research project for early detection of Alzheimer and Parkinson diseases. This technology currently supports three sensing solutions based on your application needs. The wearable core body temperature sensing solutions are described in details here.
Abstract: Alzheimer (AD), and Parkinson Diseases (PD) are reported to manifest themselves in changes to the circadian rhythm. A novel virtual wearable wrist-worn sensor, deployable in free living conditions, enables long-term predictive monitoring of the core body temperature, which is the only health marker directly linked to the circadian rhythm. The goal is to distinguish between normal and pathological core body temperature trajectories.
Do you want to find out more about the project ?
A description of the project is available as a PDF
A short video by Schweizer Radio und Fernsehen relates well the advantages of Core Body Temperature monitoring for Individual Health Monitoring including Sleep and Circadian Cycle Tracking:
N.B. For copyright reasons, this video is only available in Switzerland.
A growing market opportunity.
The wearable market is growing all over the world, with 297 million devices expected globally in 2023. Wearables are useful devices to track several activities, especially related to sports and healthcare. In this particular case, they are seen as enablers of early diagnosis and prevention of diseases. This is an important function to slow down the cost explosion in the healthcare system, driven by an aging population. Big technological players are already developing wearable devices, together with a bunch of small and medium innovative companies that are entering the market every year. Hence, it is a very dynamic ecosystem, and greenTEG’s sensors allow the development of new devices and functionalities with potentially a great impact.
At the same time, the market for personalized early detection of neurodegenerative diseases is growing: With an increasing average life expectancy, neurodegenerative diseases became a significant health risk factor in today’s aging societies worldwide.
In Switzerland alone, 150000 patients are suffering from dementia-related diseases (not only Alzheimer’s). In the EU the expected burden of neurodegenerative diseases is 357 billion EUR by 2050.
Although most of the diagnosed individuals are aged over 65 years, the risk age for developing a neurodegenerative disease starts as early as 40 years old, and early symptoms are often ignored or misdiagnosed. Preventive diagnosis is of critical importance to help manage this growing issue, and many institutions are already actively looking for the best solutions for that.
Therefore, there is a significant opportunity for developing a sensor that helps to early diagnose these diseases through non-invasive methods.
A smartwatch equipped with the hardware and software for early detection of neurodegenerative conditions could lead to more effective treatment, a better quality of life, and cost cuts for the healthcare system [Pagan 2012, Todd 2008].
A wearable is especially suitable for that purpose since it monitors every individual in real-time for an extended period (rather than only 2 during short time checkouts), detecting in advance those symptoms that announce health problems.
Do you need more information about Core body temperature monitoring for early detection of neurodegenerative diseases ?
We will gladly discuss the potential application for your specific case !
The science behind neurodegenerative diseases, circadian cycles, and core body temperature.
The current project is based on previous research about non-clinical detection of the symptoms indicative of neurodegenerative diseases using temperature readings linked to the circadian rhythms.
Several studies indicate that patients suffering from neurodegenerative diseases exhibit abnormalities in the circadian cycle [Zhong 2013, Satlin 1995].
More specifically, some of them show disrupted sleep and higher core body temperature during the night compared to healthy individuals (Pierangeli 2001).
Alzheimer’s disease patients have also a phase delay in the circadian cycle [Satlin, 1995].
However, this research couldn’t be applied to consumer products due to the lack of devices that allowed for non-invasive and reliable CBT measurements.
greenTEG’s R&D goal is to close the gap developing a sensor and algorithm for non-invasive CBT estimation.
Thus, greenTEG aims to open a path towards consumer devices capable of diagnosing symptoms of neurodegenerative diseases manifested by circadian rhythm irregularities.
A comparison of tympanic with core body temperature in stroke patients was performed by Ajčević et al. (2022) and reported in the Sensors journal. This work highlights the potential of core body temperature monitoring performed with greenTEG’s technology as a method to track reliably stroke patients body temperature compared to standard temperature measurements. Find out more here.
To go further, some recommended literature:
- Find out more about other MedTech use cases, here.
- All the peer-reviewed publications can be found here.
- Pagan FL. Improving outcomes through early diagnosis of Parkinson’s disease. Am J Manag Care. 2012, Sep; 18 (7 Suppl): S176.82.
- Pierangeli G, et al. Nocturnal body core temperature falls in Parkinson’s disease but not in multiple system atrophy. Mov Disord. 2001; 16:226–232.
- Satlin A, Volicer L, Stopa EG, Harper D. Circadian locomotor activity and core-body temperature rhythms in Alzheimer’s disease. Neurobiol Aging 1995; 16:765-71.
- Todd, S and Passmore, P. Alzheimer’s Disease – The Importance of Early Detection. European Neurological Review, 2008;3(2):18-21.
- Zhong G, Bolitho S, Grunstein R, Naismith SL, Lewis SJG. The Relationship between Thermoregulation and REM Sleep Behaviour Disorder in Parkinson’s disease. PLoS ONE 8(8), 2013
- Ajčević, Miloš, et al. “A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting.” Sensors 22.13 (2022): 4760.